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- Bed4a57b81e7af191db3a57f50154a584 NCIT_P378 "NCI" @default.
- Bed4a57b81e7af191db3a57f50154a584 type Axiom @default.
- Bed4a57b81e7af191db3a57f50154a584 annotatedProperty IAO_0000115 @default.
- Bed4a57b81e7af191db3a57f50154a584 annotatedSource NCIT_C65318 @default.
- Bed4a57b81e7af191db3a57f50154a584 annotatedTarget "The hydrochloride salt of chloroquine, a synthetic quinoline with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids." @default.