Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bed5db3fdd688185659bbc61583b74e8b> ?p ?o ?g. }
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- Bed5db3fdd688185659bbc61583b74e8b NCIT_P378 "NCI" @default.
- Bed5db3fdd688185659bbc61583b74e8b type Axiom @default.
- Bed5db3fdd688185659bbc61583b74e8b annotatedProperty IAO_0000115 @default.
- Bed5db3fdd688185659bbc61583b74e8b annotatedSource NCIT_C1549 @default.
- Bed5db3fdd688185659bbc61583b74e8b annotatedTarget "A single-chain immunotoxin consisting of Fv fragments of the BR96 monoclonal antibody (MoAb) and a truncated Pseudomonas exotoxin (PE40) that lacking the binding domain. MoAb BR96 specifically binds to Lewis Y-related carbohydrate antigen, a cell surface antigen overexpressed in many carcinomas. After internalization, PE40 causes ADP-ribosylation of transcription elongation factor 2, thereby inactivating elongation factor 2 and inhibiting protein synthesis in the cancer cells." @default.