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- Bed8d874215bbf8cbfa8619cfbf02da9e NCIT_P378 "NCI" @default.
- Bed8d874215bbf8cbfa8619cfbf02da9e type Axiom @default.
- Bed8d874215bbf8cbfa8619cfbf02da9e annotatedProperty IAO_0000115 @default.
- Bed8d874215bbf8cbfa8619cfbf02da9e annotatedSource NCIT_C173713 @default.
- Bed8d874215bbf8cbfa8619cfbf02da9e annotatedTarget "A preparation of T-lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) specific for glypican-3 (GPC3), with potential immunostimulating and antineoplastic activities. Upon administration, anti-GPC3-CAR T-lymphocytes TAK-102 specifically targets and binds to GPC3-expressing tumor cells, resulting in tumor cell lysis. GPC3, a heparan sulfate proteoglycan and a member of the glypican family, is overexpressed on certain tumor cell types while minimally expressed on normal, healthy cells; GPC3 plays an important role in cellular proliferation and differentiation." @default.