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- Bef0e9ad33e4df09c07caab3e018b4973 NCIT_P378 "KEGG" @default.
- Bef0e9ad33e4df09c07caab3e018b4973 type Axiom @default.
- Bef0e9ad33e4df09c07caab3e018b4973 annotatedProperty NCIT_P325 @default.
- Bef0e9ad33e4df09c07caab3e018b4973 annotatedSource NCIT_C91500 @default.
- Bef0e9ad33e4df09c07caab3e018b4973 annotatedTarget "Primary immunodeficiencies (PIs) are a heterogeneous group of disorders, which affect cellular and humoral immunity or non-specific host defense mechanisms mediated by complement proteins, and cells such as phagocytes and natural killer (NK) cells. These disorders of the immune system cause increased susceptibility to infection, autoimmune disease, and malignancy. Most of PIs are due to genetic defects that affect cell maturation or function at different levels during hematopoiesis. Disruption of the cellular immunity is observed in patients with defects in T cells or both T and B cells. These cellular immunodeficiencies comprise 20% of all PIs. Disorders of humoral immunity affect B-cell differentiation and antibody production. They account for 70% of all PIs." @default.