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- Bef7dd35d4f55e3c55453e827e07d19cf NCIT_P378 "NCI" @default.
- Bef7dd35d4f55e3c55453e827e07d19cf type Axiom @default.
- Bef7dd35d4f55e3c55453e827e07d19cf annotatedProperty IAO_0000115 @default.
- Bef7dd35d4f55e3c55453e827e07d19cf annotatedSource NCIT_C42771 @default.
- Bef7dd35d4f55e3c55453e827e07d19cf annotatedTarget "A device usually made of plastic or metal, inserted into the uterus to prevent conception. IUCD can be a coil, loop, triangle, or T in shape; its material can be impregnated with a pharmaceutical agent. The primary action of all IUCDs is the induction of a foreign-body reaction within the endometrium. This sterile inflammatory process is toxic to gametes, primarily spermatozoa, and effectively prevents viable sperm from passing into the fallopian tubes. The copper-bearing device has an independent toxic effect on spermatozoa. The progestin-releasing devices produce changes in endometrial architecture and function that reduce the potential for implantation of a fertilized egg. The progestin effect on the cervical mucus also reduces the penetrability of sperm." @default.