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- Befb639a1f1ff43f39a7987b05a532c5b NCIT_P378 "NCI" @default.
- Befb639a1f1ff43f39a7987b05a532c5b type Axiom @default.
- Befb639a1f1ff43f39a7987b05a532c5b annotatedProperty IAO_0000115 @default.
- Befb639a1f1ff43f39a7987b05a532c5b annotatedSource NCIT_C133543 @default.
- Befb639a1f1ff43f39a7987b05a532c5b annotatedTarget "A humanized monoclonal immunoglobulin G1 anti-P-selectin antibody with vaso-protective and anti-vaso-occlusive properties. Upon administration, crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand-1 (PSGL-1; SELPLG) on neutrophils and monocytes. P-selectin, a glycoprotein that functions as a cell adhesion molecule (CAM), translocates to the surface of activated endothelial cells and platelets, upon stimulation, where it binds to its ligand and mediates the rolling of platelets and neutrophils on activated endothelial cells. Therefore, blockade of p-selectin may inhibit platelet aggregation, maintain blood flow and minimize sickle cell-related pain crises (SCPC)." @default.