Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Befe6bff1002022a28ab637c0714f77ee> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Befe6bff1002022a28ab637c0714f77ee NCIT_P378 "NCI" @default.
- Befe6bff1002022a28ab637c0714f77ee type Axiom @default.
- Befe6bff1002022a28ab637c0714f77ee annotatedProperty IAO_0000115 @default.
- Befe6bff1002022a28ab637c0714f77ee annotatedSource NCIT_C199480 @default.
- Befe6bff1002022a28ab637c0714f77ee annotatedTarget "A radioconjugate composed of the melanocyte-stimulating hormone receptor (MSHR; melanocortin-1 receptor; MC1R; melanin-activating peptide receptor; melanotropin receptor)-targeting peptide, VMT01, conjugated to the alpha-emitting radioisotope lead Pb 212, with potential antineoplastic activity. Upon administration, lead Pb 212-VMT01 targets and binds to MC1R-expressing tumor cells. This allows for the specific delivery of a cytotoxic dose of alpha radiation to MC1R-expressing tumor cells. MC1R, a G protein-coupled receptor expressed by melanocytes that binds to melanocortins, is involved in regulating mammalian skin and hair color. It is upregulated on the surface of metastatic melanoma cells." @default.