Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bf0393be33bcae4ee3d787f4706b9446b> ?p ?o ?g. }
Showing items 1 to 8 of
8
with 100 items per page.
- Bf0393be33bcae4ee3d787f4706b9446b hasDbXref "GOC:di" @default.
- Bf0393be33bcae4ee3d787f4706b9446b hasDbXref "PMID:25655284" @default.
- Bf0393be33bcae4ee3d787f4706b9446b hasDbXref "PMID:25878052" @default.
- Bf0393be33bcae4ee3d787f4706b9446b hasDbXref "PMID:26851544" @default.
- Bf0393be33bcae4ee3d787f4706b9446b type Axiom @default.
- Bf0393be33bcae4ee3d787f4706b9446b annotatedProperty IAO_0000115 @default.
- Bf0393be33bcae4ee3d787f4706b9446b annotatedSource GO_0097720 @default.
- Bf0393be33bcae4ee3d787f4706b9446b annotatedTarget "Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression." @default.