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- Bf039dcf78a9973bf5fbc2723310fc042 NCIT_P378 "NCI" @default.
- Bf039dcf78a9973bf5fbc2723310fc042 type Axiom @default.
- Bf039dcf78a9973bf5fbc2723310fc042 annotatedProperty IAO_0000115 @default.
- Bf039dcf78a9973bf5fbc2723310fc042 annotatedSource NCIT_C1015 @default.
- Bf039dcf78a9973bf5fbc2723310fc042 annotatedTarget "A microbial metabolite and dipeptide with potential immunomodulatory and antitumor activities. Ubenimex competitively inhibits many aminopeptidases, including B, N and leucine aminopeptidases. Aminopeptidases has been implicated in the process of cell adhesion and invasion of tumor cells. Therefore, inhibiting aminopeptidases may partially attribute to the antitumor effect of ubenimex. This agent also activates T lymphocyte, macrophage and bone marrow stem cell as well as stimulates release of interleukin-1 and -2, thus further enhances its antitumor activity." @default.