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- Bf157954c6958698b9024149c1b0a4241 NCIT_P378 "NCI" @default.
- Bf157954c6958698b9024149c1b0a4241 type Axiom @default.
- Bf157954c6958698b9024149c1b0a4241 annotatedProperty IAO_0000115 @default.
- Bf157954c6958698b9024149c1b0a4241 annotatedSource NCIT_C47644 @default.
- Bf157954c6958698b9024149c1b0a4241 annotatedTarget "The nitrate salt form of oxiconazole, a broad spectrum imidazole derivative with antifungal activity. Although the exact mechanism of action has yet to be fully elucidated, oxiconazole, like other azole antifungals, most likely inhibits the cytochrome P450-dependent demethylation of lanosterol. This prevents the synthesis of ergosterol which is a crucial component of fungal cell membrane. By disrupting fungal cell membrane synthesis and integrity, oxiconazole alters fungal cell membrane permeability, promotes loss of essential intracellular components and eventually inhibits fungal cell growth." @default.