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- Bf1af0f759c5c17ee2c95bbf9f2a0bbb0 NCIT_P378 "NCI" @default.
- Bf1af0f759c5c17ee2c95bbf9f2a0bbb0 type Axiom @default.
- Bf1af0f759c5c17ee2c95bbf9f2a0bbb0 annotatedProperty IAO_0000115 @default.
- Bf1af0f759c5c17ee2c95bbf9f2a0bbb0 annotatedSource NCIT_C1041 @default.
- Bf1af0f759c5c17ee2c95bbf9f2a0bbb0 annotatedTarget "The hydrochloride salt of a semi-synthetic, beta-lactamase-resistant, fourth-generation cephalosporin antibiotic derived from an Acremonium fungal species with broad-spectrum bactericidal activity. Administered parenterally, cefepime inhibits bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, resulting in a reduction of bacterial cell wall stability and cell lysis. This agent is more active against a variety of Gram-positive pathogens compared to third-generation cephalosporins." @default.