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- Bf2046f0d3a9c942ef72b25d3d57affe3 NCIT_P378 "NCI" @default.
- Bf2046f0d3a9c942ef72b25d3d57affe3 type Axiom @default.
- Bf2046f0d3a9c942ef72b25d3d57affe3 annotatedProperty IAO_0000115 @default.
- Bf2046f0d3a9c942ef72b25d3d57affe3 annotatedSource NCIT_C66937 @default.
- Bf2046f0d3a9c942ef72b25d3d57affe3 annotatedTarget "A semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance (MDR), P-glycoprotein (P-gp) efflux pump and may be useful for treating multidrug-resistant tumors. In addition, cabazitaxel penetrates the blood-brain barrier (BBB)." @default.