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- Bf217045cf674526969082261d5e4c0a5 NCIT_P378 "NCI" @default.
- Bf217045cf674526969082261d5e4c0a5 type Axiom @default.
- Bf217045cf674526969082261d5e4c0a5 annotatedProperty IAO_0000115 @default.
- Bf217045cf674526969082261d5e4c0a5 annotatedSource NCIT_C61893 @default.
- Bf217045cf674526969082261d5e4c0a5 annotatedTarget "A short-acting, beta-adrenergic receptor agonist with bronchodilator activity. Pirbuterol selectively binds to beta-2 adrenergic receptors in bronchial smooth muscle, thereby activating intracellular adenyl cyclase, an enzyme that catalyzes the conversion of adenosine triphosphate (ATP) to cyclic-3',5'-adenosine monophosphate (cAMP). Increased cAMP levels cause relaxation of bronchial smooth muscle, relieve bronchospasms, improve mucociliary clearance and inhibit the release of mediators of immediate hypersensitivity from cells, especially from mast cells." @default.