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- Bf2ea70a0aad135832be445dcc451f5d9 NCIT_P378 "NCI" @default.
- Bf2ea70a0aad135832be445dcc451f5d9 type Axiom @default.
- Bf2ea70a0aad135832be445dcc451f5d9 annotatedProperty IAO_0000115 @default.
- Bf2ea70a0aad135832be445dcc451f5d9 annotatedSource NCIT_C346 @default.
- Bf2ea70a0aad135832be445dcc451f5d9 annotatedTarget "A zinc-dependent enzyme isolated from a strain of the bacterium Pseudomonas. Because glucarpidase rapidly hydrolyzes methotrexate into inactive metabolites, it may be useful as a rescue agent for methotrexate-induced nephrotoxicity. In antibody-directed enzyme prodrug therapy (ADEPT), this agent is conjugated with an antibody that binds to a specific tumor cell type, allowing for glucarpidase-catalyzed activation of a co-administered prodrug at the site of the tumor." @default.