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- Bf301d54f4ef9bc8f7769da8770f072eb NCIT_P378 "NCI" @default.
- Bf301d54f4ef9bc8f7769da8770f072eb type Axiom @default.
- Bf301d54f4ef9bc8f7769da8770f072eb annotatedProperty IAO_0000115 @default.
- Bf301d54f4ef9bc8f7769da8770f072eb annotatedSource NCIT_C26666 @default.
- Bf301d54f4ef9bc8f7769da8770f072eb annotatedTarget "An orally active synthetic enantiomer of flurbiprofen. Tarenflurbil activates c-Jun N terminal kinase, increases AP-1 binding to DNA, and downregulates cyclin D1 expression, resulting in arrest of tumor cells in the G1 phase of the cell cycle and apoptosis. This agent also affects the expression of nuclear factor kappa B, a rapid response transcription factor that stimulates the immune response to tumor cells. R-flurbiprofen does not inhibit the enzyme cyclo-oxygenase." @default.