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- Bf32df989b0dff50abfb5e85c1641dd10 NCIT_P378 "NCI" @default.
- Bf32df989b0dff50abfb5e85c1641dd10 type Axiom @default.
- Bf32df989b0dff50abfb5e85c1641dd10 annotatedProperty IAO_0000115 @default.
- Bf32df989b0dff50abfb5e85c1641dd10 annotatedSource NCIT_C201073 @default.
- Bf32df989b0dff50abfb5e85c1641dd10 annotatedTarget "An antibody-drug conjugate (ADC) composed of a human monoclonal antibody directed against the tumor-associated antigen (TAA) Claudin 18.2 (CLDN18.2; A2 isoform of claudin-18) conjugated to the microtubule-disrupting cytotoxic agent monomethyl auristatin E (MMAE), with potential antineoplastic activity. Upon administration of anti-CLDN18.2 ADC EO-3021, the anti-CLDN18.2 monoclonal antibody moiety specifically targets and binds to CLDN18.2 expressed on tumor cells. Upon internalization and the release of MMAE, MMAE targets and binds to tubulin, and inhibits microtubule polymerization. This results in G2/M phase cell cycle arrest and apoptosis in CLDN18.2-expressing tumor cells. CLDN18.2, a tight junction protein and stomach-specific isoform of claudin-18, is expressed on a variety of tumor cells. Its expression in healthy tissues is strictly confined to short-lived differentiated epithelial cells of the gastric mucosa." @default.