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- Bf336aeaa9080badbe538417c0608a0d5 NCIT_P378 "NCI" @default.
- Bf336aeaa9080badbe538417c0608a0d5 type Axiom @default.
- Bf336aeaa9080badbe538417c0608a0d5 annotatedProperty IAO_0000115 @default.
- Bf336aeaa9080badbe538417c0608a0d5 annotatedSource NCIT_C96795 @default.
- Bf336aeaa9080badbe538417c0608a0d5 annotatedTarget "An orally available inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, ABT-767 selectively binds to PARP 1 and 2, thereby preventing repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of DNA strand breaks and promotes genomic instability eventually leading to apoptosis. ABT-767 may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins that signal and recruit other proteins to repair damaged DNA and can be activated by single strand DNA (ssDNA) breaks." @default.