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- Bf46d9c56b6924102aeaa8c7f93c63f87 NCIT_P378 "NCI" @default.
- Bf46d9c56b6924102aeaa8c7f93c63f87 type Axiom @default.
- Bf46d9c56b6924102aeaa8c7f93c63f87 annotatedProperty IAO_0000115 @default.
- Bf46d9c56b6924102aeaa8c7f93c63f87 annotatedSource NCIT_C156249 @default.
- Bf46d9c56b6924102aeaa8c7f93c63f87 annotatedTarget "An orally bioavailable and selective inhibitor of the anti-apoptotic protein B-cell lymphoma 2 (Bcl-2), with potential pro-apoptotic and antineoplastic activities. Upon oral administration, lisaftoclax targets, binds to and inhibits the activity of Bcl-2. This restores apoptotic processes in tumor cells. Bcl-2 is overexpressed in many cancers and plays an important role in the negative regulation of apoptosis; its expression is associated with increased drug resistance and tumor cell survival." @default.