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- Bf536ebfa37450262e35d1bf55f809c2a NCIT_P378 "NCI" @default.
- Bf536ebfa37450262e35d1bf55f809c2a type Axiom @default.
- Bf536ebfa37450262e35d1bf55f809c2a annotatedProperty IAO_0000115 @default.
- Bf536ebfa37450262e35d1bf55f809c2a annotatedSource NCIT_C61867 @default.
- Bf536ebfa37450262e35d1bf55f809c2a annotatedTarget "The hydrochloride salt form of olopatadine, a dual action selective histamine H1 receptor antagonist and mast cell stabilizer with anti-allergic activity. Olopatadine stabilizes mast cells and prevents histamine release from mast cells. In addition, this agent also blocks histamine H1 receptors, thereby preventing histamine from binding to these receptors. Both actions prevent the effects of histamine on capillaries, bronchial smooth muscle, and gastrointestinal (GI) smooth muscle, including histamine-induced vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of GI smooth muscle. This drug also prevents histamine-induced pain and itching of mucous membranes." @default.