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- Bf542ae17b1b5bbe2a2a529907c760592 NCIT_P378 "NCI" @default.
- Bf542ae17b1b5bbe2a2a529907c760592 type Axiom @default.
- Bf542ae17b1b5bbe2a2a529907c760592 annotatedProperty IAO_0000115 @default.
- Bf542ae17b1b5bbe2a2a529907c760592 annotatedSource NCIT_C35778 @default.
- Bf542ae17b1b5bbe2a2a529907c760592 annotatedTarget "A stromal tumor that originates from the interstitial cells of Cajal. It may involve any part of the gastrointestinal tract. The majority of cases occur in the stomach. Morphologic variants include the epithelioid cell type, spindle cell type, and mixed cell type. Most cases contain KIT- or PDGFRA-activating mutations. Lesions with a diameter greater than 10cm and more than 5 mitotic figures per 50HPF tend to have a more aggressive clinical course. Until recently, surgery has been the only effective therapy for this tumor. However, many patients still experience recurrence. A KIT tyrosine kinase inhibitor, imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the treatment of relapsed and unresectable cases." @default.