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- Bf5431fc5a4911d50cf103e700b45f492 NCIT_P378 "NCI" @default.
- Bf5431fc5a4911d50cf103e700b45f492 type Axiom @default.
- Bf5431fc5a4911d50cf103e700b45f492 annotatedProperty IAO_0000115 @default.
- Bf5431fc5a4911d50cf103e700b45f492 annotatedSource NCIT_C66181 @default.
- Bf5431fc5a4911d50cf103e700b45f492 annotatedTarget "A synthetic topical glucocorticoid receptor (GR) agonist with anti-inflammatory, anti-pruritic and vasoconstrictive properties. Upon administration, mometasone binds to cytoplasmic GRs and subsequently activates GR-mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, mometasone appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from phospholipid membrane by phospholipase A2." @default.