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- Bf5a0609c0982485c8fef719e1fd373f7 NCIT_P378 "NCI" @default.
- Bf5a0609c0982485c8fef719e1fd373f7 type Axiom @default.
- Bf5a0609c0982485c8fef719e1fd373f7 annotatedProperty IAO_0000115 @default.
- Bf5a0609c0982485c8fef719e1fd373f7 annotatedSource NCIT_C124655 @default.
- Bf5a0609c0982485c8fef719e1fd373f7 annotatedTarget "Human autologous lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the cancer/testis antigen NY-ESO-1, with potential antineoplastic activity. Upon isolation, transduction, expansion ex vivo, and reintroduction into the patient, the autologous T-lymphocytes expressing NY-ESO-1-C259-specific enhanced T-cell receptors bind to NY-ESO-1-overexpressing tumor cells. This may result in the specific cytotoxic T-lymphocyte (CTL) killing of NY-ESO-1-positive cancer cells. NY-ESO-1, a tumor-associated antigen (TAA), is found in normal testis and on the surface of various tumor cell types; the TCR is specific for SLLMWITQC, an NY-ESO-1-derived peptide, in a complex with human leukocyte antigen (HLA) A2 peptide." @default.