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- Bf5fa71c5d3d83d47782986d1f06677e8 NCIT_P378 "NCI" @default.
- Bf5fa71c5d3d83d47782986d1f06677e8 type Axiom @default.
- Bf5fa71c5d3d83d47782986d1f06677e8 annotatedProperty IAO_0000115 @default.
- Bf5fa71c5d3d83d47782986d1f06677e8 annotatedSource NCIT_C76665 @default.
- Bf5fa71c5d3d83d47782986d1f06677e8 annotatedTarget "The hydrochloride salt of alvespimycin, an analogue of the antineoplastic benzoquinone antibiotic geldanamycin. Alvespimycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins. Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction." @default.