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- Bf6cf5a6a714d248f3aaef3cf3e40fb2f NCIT_P378 "NCI" @default.
- Bf6cf5a6a714d248f3aaef3cf3e40fb2f type Axiom @default.
- Bf6cf5a6a714d248f3aaef3cf3e40fb2f annotatedProperty IAO_0000115 @default.
- Bf6cf5a6a714d248f3aaef3cf3e40fb2f annotatedSource NCIT_C17286 @default.
- Bf6cf5a6a714d248f3aaef3cf3e40fb2f annotatedTarget "Ubiquitously or widely expressed human cAMP Responsive Element Binding Proteins (bZIP/CREB Family) are conserved nuclear bZIP domain dimeric transcription factors that bind to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and induce gene transcription in response to cAMP signaling pathways. CREB proteins bind to DNA as a homodimer or a heterodimer with JUN/c-Jun or ATF2/CREBP1. Increased cAMP levels following stimulation activate cAMP-dependent protein kinase A, which phosphorylates CREB proteins that stimulate transcription of cAMP-responsive genes. Calcium-regulated CREB transcription factors integrate calcium and cAMP signals. cAMP pathways provide a chief means by which cellular growth, differentiation, and function can be influenced by extracellular signals. (NCI)" @default.