Matches in Ubergraph for { <https://frink.apps.renci.org/.well-known/genid/Bf71b63d98b2a6e7a2c74a670c5afc933> ?p ?o ?g. }
Showing items 1 to 5 of
5
with 100 items per page.
- Bf71b63d98b2a6e7a2c74a670c5afc933 NCIT_P378 "NCI" @default.
- Bf71b63d98b2a6e7a2c74a670c5afc933 type Axiom @default.
- Bf71b63d98b2a6e7a2c74a670c5afc933 annotatedProperty IAO_0000115 @default.
- Bf71b63d98b2a6e7a2c74a670c5afc933 annotatedSource NCIT_C156739 @default.
- Bf71b63d98b2a6e7a2c74a670c5afc933 annotatedTarget "A radioconjugate composed of a tumor-selective fluorescent imaging agent containing silica-based nanoparticles labeled with a near-infrared (NIR) fluorophore, cyanine 5 (Cy5), and surrounded by polyethylene glycol (PEG) chains attached to cyclic arginine-glycine-aspartic acid-tyrosine) (cyclo-(Arg-Gly-Asp-Tyr; cRGDY) peptides (C' dots; Cornell prime dots; cRGDY-PEG-C' dots), and linked, via the chelator desferrioxamine (DFO), to the radioisotope zirconium Zr 89 (Zr89), with potential diagnostic properties upon positron emission tomography (PET) imaging. Upon intradermal administration of the zirconium Zr 89 cRGDY PEG-Cy5-C' dots, the cRGDY moiety selectively binds to alphaVbeta3 integrin expressed on tumor cells. Upon binding, the radioisotope moiety may be detected using PET, thereby allowing the imaging and quantification of integrin-expressing tumor cells as well as the visualization of the distribution, uptake and removal within tumor tissues. The fluorescence imaging agent is used to visualize alphaVbeta3-expressing tumor cells and assess the degree of both tumor metastasis and sentinel lymph node (SLN) trafficking. Integrins are transmembrane glycoproteins upregulated on proliferating tumor vessel endothelial cells and various cancer cells; their overexpression has been associated with neovascularization, differentiation, proliferation of tumor cells, metastasis and an overall poor prognosis." @default.