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- Bf839164c037160f09c0cca2e8604dd84 NCIT_P378 "NCI" @default.
- Bf839164c037160f09c0cca2e8604dd84 NCIT_P381 "Semin Thromb Hemost 2000;26(5):561-9" @default.
- Bf839164c037160f09c0cca2e8604dd84 type Axiom @default.
- Bf839164c037160f09c0cca2e8604dd84 annotatedProperty IAO_0000115 @default.
- Bf839164c037160f09c0cca2e8604dd84 annotatedSource NCIT_C17293 @default.
- Bf839164c037160f09c0cca2e8604dd84 annotatedTarget "There are three signaling VEGF receptors. The VEGF family members PIGF and VEGF-B with exclusive binding capacities to the VEGFR-1 can influence monocyte activation and differentiation. The VEGFR-2 and VEGFR-3 binding VEGF homologues, VEGF-C and VEGF-D, are mitogens for both vascular and lymphatic endothelial cells. The orf virus encoded VEGF-E homologue binds and activates only the VEGFR-2 and thus may be the prototype of a vascular endothelial cell-specific growth factor. Further specific activities of VEGF and its homologues result from receptor-specific signaling and differential expression of ligands or receptors. A naturally occurring soluble form of the VEGFR-1 suggests a regulatory role for this receptor." @default.