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- Bf8625460ecfeee84dac1906eec1f410f NCIT_P378 "NCI" @default.
- Bf8625460ecfeee84dac1906eec1f410f type Axiom @default.
- Bf8625460ecfeee84dac1906eec1f410f annotatedProperty IAO_0000115 @default.
- Bf8625460ecfeee84dac1906eec1f410f annotatedSource NCIT_C1831 @default.
- Bf8625460ecfeee84dac1906eec1f410f annotatedTarget "A quinolone derivative with potential antineoplastic activity. Semaxanib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), which may inhibit VEGF-stimulated endothelial cell migration and proliferation and reduce the tumor microvasculature. This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells." @default.