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- Bf8a99ffb8f251540c726f75206fc8a65 NCIT_P378 "NCI" @default.
- Bf8a99ffb8f251540c726f75206fc8a65 type Axiom @default.
- Bf8a99ffb8f251540c726f75206fc8a65 annotatedProperty IAO_0000115 @default.
- Bf8a99ffb8f251540c726f75206fc8a65 annotatedSource NCIT_C29404 @default.
- Bf8a99ffb8f251540c726f75206fc8a65 annotatedTarget "A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity. Bioactivation of aziridinylbenzoquinone RH1 occurs through the two-electron reduction of the quinone to the hydroquinone by the two-electron quinone reductase DT-diaphorase (DTD). The resultant hydroquinone selectively alkylates and cross-links DNA at the 5'-GNC-3' sequence, inihibiting DNA replication, inducing apoptosis, and inhibiting tumor cell proliferation. DTD is over-expressed in many tumors relative to normal tissue, including lung, colon, breast and liver tumors." @default.