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- Bf90c693dd77bd38455ec75c59897fd1d NCIT_P378 "NCI" @default.
- Bf90c693dd77bd38455ec75c59897fd1d type Axiom @default.
- Bf90c693dd77bd38455ec75c59897fd1d annotatedProperty IAO_0000115 @default.
- Bf90c693dd77bd38455ec75c59897fd1d annotatedSource NCIT_C1584 @default.
- Bf90c693dd77bd38455ec75c59897fd1d annotatedTarget "The hydrochloride salt form of loperamide, a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity. Loperamide acts on the mu-receptors in the intestinal mucosa. This leads to a decrease in gastrointestinal motility by decreasing the circular and longitudinal smooth muscle activity of the intestinal wall. This slows intestinal transit and allows for more water and electrolyte absorption from the intestines. Loperamide is not significantly absorbed from the gut and does not cross the blood-brain barrier. Therefore it has no central nervous system effects." @default.