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- Bf966b3be6da52bbf79302aa41bc966b0 NCIT_P378 "NCI" @default.
- Bf966b3be6da52bbf79302aa41bc966b0 type Axiom @default.
- Bf966b3be6da52bbf79302aa41bc966b0 annotatedProperty IAO_0000115 @default.
- Bf966b3be6da52bbf79302aa41bc966b0 annotatedSource NCIT_C80325 @default.
- Bf966b3be6da52bbf79302aa41bc966b0 annotatedTarget "The trisodium salt form of zoledronate, a synthetic imidazole, third generation bisphosphonate analog of pyrophosphate with antiresorptive activity. Zoledronate binds to hydroxyapatite crystals in the bone matrix and inhibits farnesyl pyrophosphate (diphosphate) synthase, thereby preventing protein prenylation within the mevalonate pathway. This leads to the loss of downstream metabolites essential for osteoclast function, leading to the induction of apoptosis and eventually, osteoclast-cell death. By preventing osteoclast-mediated bone resorption, zoledronate decreases bone turnover and stabilizes the bone matrix." @default.