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- Bf9a47e3b31a08255e39e02008f92cb3b NCIT_P378 "NCI" @default.
- Bf9a47e3b31a08255e39e02008f92cb3b type Axiom @default.
- Bf9a47e3b31a08255e39e02008f92cb3b annotatedProperty IAO_0000115 @default.
- Bf9a47e3b31a08255e39e02008f92cb3b annotatedSource NCIT_C47559 @default.
- Bf9a47e3b31a08255e39e02008f92cb3b annotatedTarget "The hydrochloride salt form of hydroxyzine, a piperazine histamine H1-receptor antagonist with anti-allergic, antispasmodic, sedative, anti-emetic and anti-anxiety properties. Hydroxyzine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. In addition, hydroxyzine hydrochloride crosses the blood-brain barrier and acts on the histamine H1-receptors in the central nervous system. (NCI05)" @default.