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- Bfa1c49bc6e98f9ec62202c1867af305b NCIT_P378 "NCI" @default.
- Bfa1c49bc6e98f9ec62202c1867af305b type Axiom @default.
- Bfa1c49bc6e98f9ec62202c1867af305b annotatedProperty IAO_0000115 @default.
- Bfa1c49bc6e98f9ec62202c1867af305b annotatedSource NCIT_C2337 @default.
- Bfa1c49bc6e98f9ec62202c1867af305b annotatedTarget "The sodium salt of butyrate with potential antineoplastic activity. Butyrate, a short chain fatty acid, competitively binds to the zinc sites of class I and II histone deacetylases (HDACs). This binding affects hyperacetylation of histones, resulting in a modified DNA conformation, which subsequently leads to the uncoiling or relaxing of chromatin. Enhanced accessibility of chromatin to transcription-regulatory complexes leads to increased transcriptional activation of various epigenetically suppressed genes. Butyrate, a HDAC inhibitor, induces cell cycle arrest in G1 or G2/M and also increases the expression of other genes and proteins involved in cellular differentiation and apoptotic signaling." @default.