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- Bfa31aa2584cc26e05634d2e9edc7f4c7 NCIT_P378 "NCI" @default.
- Bfa31aa2584cc26e05634d2e9edc7f4c7 type Axiom @default.
- Bfa31aa2584cc26e05634d2e9edc7f4c7 annotatedProperty IAO_0000115 @default.
- Bfa31aa2584cc26e05634d2e9edc7f4c7 annotatedSource NCIT_C71721 @default.
- Bfa31aa2584cc26e05634d2e9edc7f4c7 annotatedTarget "A small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks." @default.