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- Bfa885f60bee9b30b87a186f2bd5366c8 NCIT_P378 "NCI" @default.
- Bfa885f60bee9b30b87a186f2bd5366c8 type Axiom @default.
- Bfa885f60bee9b30b87a186f2bd5366c8 annotatedProperty IAO_0000115 @default.
- Bfa885f60bee9b30b87a186f2bd5366c8 annotatedSource NCIT_C77424 @default.
- Bfa885f60bee9b30b87a186f2bd5366c8 annotatedTarget "The acetate salt form of histrelin, a long-acting, synthetic nonapeptide analog of gonadotropin-releasing hormone (GnRH) with potential anti-tumor activity. Upon administration, histrelin binds to and activates GnRH receptors; prolonged administration results in pituitary GnRH receptor desensitization and inhibition of follicle stimulating hormone (FSH) and luteinizing hormone (LH) secretion, leading to a significant decline in testosterone production in males and may inhibit androgen receptor-positive tumor progression; in females, prolonged administration results in decreased estradiol production." @default.