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- Bfb62084d4b93b951569e608f404232a5 NCIT_P378 "NCI" @default.
- Bfb62084d4b93b951569e608f404232a5 type Axiom @default.
- Bfb62084d4b93b951569e608f404232a5 annotatedProperty IAO_0000115 @default.
- Bfb62084d4b93b951569e608f404232a5 annotatedSource NCIT_C1268 @default.
- Bfb62084d4b93b951569e608f404232a5 annotatedTarget "An orally bioavailable oxazaphosphorine prodrug with antineoplastic activity. Trofosfamide (TFF) is metabolized predominantly to the cyclophosphamide analogue ifosfamide (IFO), which is then metabolized by liver cytochrome P450s to the active isophosphoramide mustard (IPM). IPM alkylates DNA to form DNA-DNA cross-links, which may result in inhibition of DNA, RNA and protein synthesis, and ultimately lead to tumor cell apoptosis." @default.