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- Bfbe82ce1e7bf288736c62480f0bf4f8a NCIT_P378 "NCI" @default.
- Bfbe82ce1e7bf288736c62480f0bf4f8a type Axiom @default.
- Bfbe82ce1e7bf288736c62480f0bf4f8a annotatedProperty IAO_0000115 @default.
- Bfbe82ce1e7bf288736c62480f0bf4f8a annotatedSource NCIT_C65470 @default.
- Bfbe82ce1e7bf288736c62480f0bf4f8a annotatedTarget "A broad-spectrum, carbapenem antibiotic with bactericidal and beta-lactamase resistant activities. Doripenem binds to penicillin binding proteins (PBPs) located on the bacterial cell wall, particularly PBPs 2 and 3, thereby inhibiting the final transpeptidation step in the synthesis of peptidoglycan, an essential component of the bacterial cell wall. Inhibition results in a weakening and eventually lysis of the bacterial cell wall. This agent is two- to 16-fold more potent than imipenem and comparable to ertapenem and meropenem." @default.