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- Bfcc4e3e66729c71f2d7215fda6b3a88a NCIT_P378 "NCI" @default.
- Bfcc4e3e66729c71f2d7215fda6b3a88a type Axiom @default.
- Bfcc4e3e66729c71f2d7215fda6b3a88a annotatedProperty IAO_0000115 @default.
- Bfcc4e3e66729c71f2d7215fda6b3a88a annotatedSource NCIT_C71149 @default.
- Bfcc4e3e66729c71f2d7215fda6b3a88a annotatedTarget "An embolic material composed of microspheres of polyvinyl alcohol (PVA) polymers loaded with doxorubicin hydrochloride with antineoplastic activity. Doxorubicin hydrochloride-loaded microspheres may be used as a drug delivery vehicle during embolization of tumor vasculature. Doxorubicin intercalates DNA, interferes with catalytic activity of topoisomerase II, and causes DNA adducts and other DNA damage, resulting in tumor cell growth inhibition and apoptosis. When used in tumor vasculature embolization, this preparation may provide more tumor-specific treatment with doxorubicin compared to the systemic administration of doxorubicin, thereby reducing the systemic toxicity of doxorubicin." @default.