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- Bfd25cd4d4c93ef57451db0935b542c04 NCIT_P378 "NCI" @default.
- Bfd25cd4d4c93ef57451db0935b542c04 type Axiom @default.
- Bfd25cd4d4c93ef57451db0935b542c04 annotatedProperty IAO_0000115 @default.
- Bfd25cd4d4c93ef57451db0935b542c04 annotatedSource NCIT_C19816 @default.
- Bfd25cd4d4c93ef57451db0935b542c04 annotatedTarget "G1 Arrest consists of cellular biochemical mechanisms, responsive to diverse governing conditions (DNA damage, contact inhibition, growth factors, etc.), that control cellular progress through the G1 phase of the cell cycle. G1 progress is controlled by de/phosphorylated cyclin/CDK complexes. During G1, cycD/CDK phosphorylation of Rb/HDAC repressor permits E2F/DP1 transcription of genes that promote the G1/S switch and DNA replication. p53 induces p21 inhibition of cycD/CDK; Mdm2 inhibits p53/p21. TGF-b induces p15 inhibition of cycD/CDK. cAMP induces p27 inhibition of cycD/CDK. GSK3b induction of cycD degradation, and INK4, Kip, and Cdc25A regulate cycD/CDK activity." @default.