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- Bfd45e4911aa82c385fd6d07651bb9bdd NCIT_P378 "NCI" @default.
- Bfd45e4911aa82c385fd6d07651bb9bdd type Axiom @default.
- Bfd45e4911aa82c385fd6d07651bb9bdd annotatedProperty IAO_0000115 @default.
- Bfd45e4911aa82c385fd6d07651bb9bdd annotatedSource NCIT_C82676 @default.
- Bfd45e4911aa82c385fd6d07651bb9bdd annotatedTarget "A liposomal formulation of the semisynthetic camptothecin analogue irinotecan with potential antineoplastic activity. During the S phase of the cell cycle, irinotecan selectively stabilizes topoisomerase I-DNA covalent complexes, inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing lethal double-strand DNA breaks when complexes are encountered by the DNA replication machinery. Liposome encapsulation of this agent promotes efficient drug delivery into the cytosol from the endosome compartment of the cell." @default.