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- Bfdf0ab27fbf1e51195eef8ff0d5a0536 NCIT_P378 "NCI" @default.
- Bfdf0ab27fbf1e51195eef8ff0d5a0536 type Axiom @default.
- Bfdf0ab27fbf1e51195eef8ff0d5a0536 annotatedProperty IAO_0000115 @default.
- Bfdf0ab27fbf1e51195eef8ff0d5a0536 annotatedSource NCIT_C201281 @default.
- Bfdf0ab27fbf1e51195eef8ff0d5a0536 annotatedTarget "A radioconjugate composed of PNT6555, a fibroblast activation protein (FAP)-targeting moiety linked to the macrocyclic chelator 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), radiolabeled with the beta-emitting radioisotope lutetium Lu 177 (177Lu), with potential antineoplastic activity. Upon administration of lutetium Lu 177-PNT6555, the FAP-targeting moiety targets and binds to FAP-expressing cancer-associated fibroblasts (CAFs) and FAP-expressing tumor cells. Upon binding, FAP-expressing CAFs and tumor cells are destroyed by 177Lu through the specific delivery of beta particle radiation. FAP, a cell surface protein, is overexpressed on CAFs in the tumor microenvironment (TME) and certain tumor cells." @default.