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- Bfe2a86a9601d649607a8a1fbb741bf91 NCIT_P378 "NCI" @default.
- Bfe2a86a9601d649607a8a1fbb741bf91 type Axiom @default.
- Bfe2a86a9601d649607a8a1fbb741bf91 annotatedProperty IAO_0000115 @default.
- Bfe2a86a9601d649607a8a1fbb741bf91 annotatedSource NCIT_C135189 @default.
- Bfe2a86a9601d649607a8a1fbb741bf91 annotatedTarget "A formulation containing the hydrochloride salt form of diphenoxylate, a synthetic opioid of the phenylpiperidine class, and the sulfate salt form of the anticholinergic agent atropine, with antidiarrheal activity. Upon oral administration, diphenoxylate acts on opioid receptors in the gastrointestinal (GI) tract, thereby decreasing GI motility, prolonging transit time, and preventing diarrhea. Through its anticholinergic effects, atropine prevents deliberate over-usage of diphenoxylate by triggering very unpleasant side effects (SEs), such as severe weakness and nausea." @default.