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- Bfef3816d02b7a02aaf71443c3dee31da NCIT_P378 "NCI" @default.
- Bfef3816d02b7a02aaf71443c3dee31da type Axiom @default.
- Bfef3816d02b7a02aaf71443c3dee31da annotatedProperty IAO_0000115 @default.
- Bfef3816d02b7a02aaf71443c3dee31da annotatedSource NCIT_C1794 @default.
- Bfef3816d02b7a02aaf71443c3dee31da annotatedTarget "A fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites. As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells. FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand. (NCI04)" @default.