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- Bff455aefbc5e58f79dbef204145b7e2b NCIT_P378 "NCI" @default.
- Bff455aefbc5e58f79dbef204145b7e2b type Axiom @default.
- Bff455aefbc5e58f79dbef204145b7e2b annotatedProperty IAO_0000115 @default.
- Bff455aefbc5e58f79dbef204145b7e2b annotatedSource NCIT_C1398 @default.
- Bff455aefbc5e58f79dbef204145b7e2b annotatedTarget "A stable transition state analogue for an aspartate transcarbamylase-catalyzed reaction with antineoplastic activity. Sparfosic acid is a stable transition analogue of the activated complex for the reaction catalyzed by aspartate transcarbamylase, the first step in the pyrimidine biosynthetic pathway. This agent inhibits de novo pyrimidine biosynthesis and increases the extent to which fluorouracil metabolites are incorporated into RNA." @default.