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- Bff5d78db1def4e35a11339b5d7fbe6bd NCIT_P378 "NCI" @default.
- Bff5d78db1def4e35a11339b5d7fbe6bd type Axiom @default.
- Bff5d78db1def4e35a11339b5d7fbe6bd annotatedProperty IAO_0000115 @default.
- Bff5d78db1def4e35a11339b5d7fbe6bd annotatedSource NCIT_C47445 @default.
- Bff5d78db1def4e35a11339b5d7fbe6bd annotatedTarget "The phosphate salt of chloroquine, a quinoline compound with antimalarial and anti-inflammatory properties. Chloroquine is the most widely used drug against malaria, except for those cases caused by chloroquine resistant Plasmodium falciparum. Although the mechanism of action is not fully understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Chloroquine may also interfere with the biosynthesis of nucleic acids." @default.