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- W100057741 abstract "Diet and exercise are critical for preventing metabolic diseases such as type 2 diabetes, but the underlying gene expression changes associated with metabolic adaptations are unclear. We previously implemented a 16-week high-fiber low-sugar nutrition education program (N, n=16) or that plus 2 d/wk of strength training (N+ST, n=12) in Latino adolescents, and explored the intervention effects on transcriptional profiles. We measured mRNA levels pre- and post-intervention using Illumina's Expression BeadChip in white blood cells. We selected genes which were changed in N or N+ST (p<0.05, fold change >1.41, unchanged in control group) and then used Ingenuity Pathway Analysis to determine functional networks (p<0.001) and their representation in established canonical pathways (p<0.01). For N, we found 14 changed functional networks. Carbohydrate metabolism, lipid metabolism, and small molecule biochemistry were 3 of the top 5 pathways noted. For N+ST we found 33; cell-to-cell signaling and interaction, cell growth and proliferation, cellular movement, and cell development were 4 of the top 5. In addition, we found 8 canonical pathways for N, and 5 for N+ST. Results show relevant mRNA level changes after N and N+ST and their functional groupings broadly relate to the type of intervention. Further investigation of these genes may provide valuable insights into therapeutic mechanisms." @default.
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- W100057741 date "2010-04-01" @default.
- W100057741 modified "2023-09-25" @default.
- W100057741 title "Exploratory Microarray Analysis Provides Genetic Insights into Nutrition and Nutrition Plus Strength Training Interventions in Latino Adolescents" @default.
- W100057741 doi "https://doi.org/10.1096/fasebj.24.1_supplement.669.1" @default.
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