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- W10006452 abstract "Ultraviolet light (UV) irradiation of living cells induces the formation of various types of photoproducts in their DNA. These photoproducts are deleterious to the cell, interfere with m RNA production and DNA replication, and if not removed from the DNA by DNA-repair enzymes, the cells will be permanently damaged or die. Immunization of Rabbits with UV-irradiated DNA produced in our laboratory a heterogenous population of antibodies specific for various types of photoproducts in irradiated DNA. In order to study the fate of such photoproducts in various cell types and understand their biological consequences, we have applied an immunological detection technique which is far more sensitive than previously employed biochemical methods. For the purpose of identification of the various types of photoproduct excision repair, we attempted to purify the various antibody types (e.g. thymine-dimer-specific and Mminor-photoproduct-specific). Using DNA-cellulose columns in which the DNA was either unirradiated, UV-irradiated, and UV-irradiated with consequent enzymatic photoreactivation, we were able to obtain purified antibodies specific for each type of those UV-photoproducts. Their nature and specificity was determined and their use in repair studies has revealed for the first time that in addition to DNA repair of thymine-dimers, mammalian cells repair “minor” photoproducts." @default.
- W10006452 created "2016-06-24" @default.
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- W10006452 date "1978-01-01" @default.
- W10006452 modified "2023-09-23" @default.
- W10006452 title "PURIFICATION OF ANTIBODIES SPECIFIC FOR PHOTOPRODUCTS OTHER THAN PYRIMIDINE DIMERS IN ULTRAVIOLET-LIGHT IRRADIATED DNA BY AFFINITY CHROMATOGRAPHY" @default.
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- W10006452 doi "https://doi.org/10.1016/b978-0-08-022632-3.50058-1" @default.
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