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- W100081105 abstract "Few reports of lithium (Li) inhibition of adenylate cyclases meet criterion of 1) occurring at therapeutically-equivalent lithium concentrations and 2) continuing after chronic in vivo Li administration in a manner parallel to Li's clinical effect. The noradrenaline-sensitive cyclic AMP accumulation in rat brain is shown to remain inhibited after 21–28 days of chronic in vivo Li pre-treatment, at therapeutically-equivalent serum Li levels. Moreover, Li is shown to raise basal adenylate cyclase activity in rat cortical slices while reducing the nor-adrenaline-induced accumulation, suggesting a unique biphasic action. In humans receiving Li chronically the plasma cyclic AMP rise in response to epinephrine is inhibited. Parallel to this effect, the plasma cyclic GMP response is also inhibited, suggesting balanced presynaptic and postsynaptic actions of Li." @default.
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- W100081105 date "1979-01-01" @default.
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- W100081105 title "Adenylate Cyclase and the Mechanism of Lithium Action" @default.
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- W100081105 doi "https://doi.org/10.1016/b978-0-08-023089-4.50024-7" @default.
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