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• W1001099587 abstract "This chapter discusses the neural transplantation in Parkinson's disease (PD). The fetal nigral implants have provided a modest improvement in motor function in PD patients. This is consistent with the presence of small surviving grafts indicated by positron emission tomography (PET). Despite the lack of a therapeutically significant improvement in these patients, results together with the solid animal experimental data obtained with DA neuron grafting both in rodents and in non-human primates provide a strong rationale to pursue this approach. However, widespread clinical trials with neural transplantation in PD are probably not warranted at this time. From the observations made on the 2 patients reported in the chapter, the following conclusions are drawn: (1) ventral mesencephalic tissue obtained from routine elective abortions can be implanted into the brains of immunosuppressed PD patients without major complications; (2) no major graft-induced improvement of therapeutic value to the patients has been observed; (3) neurophysiological methods and the clinical test battery have detected significant but small post-operative improvements that could indicate a graft effect; and (4) PET provides an evidence of a slight increase of 18F-dopa uptake in the transplanted striatum, suggesting that small grafts have survived." @default.
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• W1001099587 date "1990-01-01" @default.
• W1001099587 modified "2023-10-15" @default.
• W1001099587 title "Chapter 83 Neural transplantation in Parkinson's disease: the Swedish experience" @default.
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• W1001099587 doi "https://doi.org/10.1016/s0079-6123(08)62666-7" @default.
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