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- W1001551729 abstract "This chapter discusses polyanionic agents and the inhibition process of phagosome–lysosome fusion. It is concerned with a hypothesis about the antagonistic effects of endocytosed polyanionic substances on phagosome–lysosome fusion in cultured macrophages. It is observed that no important macrophage function has been discerned so far that is antagonized by lysosomal accumulation of polyanions—particularly of phagocytosis, intracellular digestion, and microbicidal activities. The apparent block to fusion is indifferent to Ca2+ concentrations and cannot be imposed from the phagosomal compartment by particles of cation-exchange resins. If this “phenomenon” depends on perturbations in vesicle membranes, pinosomal membranes would appear to be embarrassing exceptions to the inhibition. They will apparently behave like phagosomal membranes, both allowing fusion with “polyanion” lysosomes. Neutral hydrocolloids mimic the behavior of polyanions with thorotrast markers, but still allow delivery of permeant or nonpermeant mobile lysosomal fluors to phagosomes." @default.
- W1001551729 created "2016-06-24" @default.
- W1001551729 creator A5051574895 @default.
- W1001551729 date "1988-01-01" @default.
- W1001551729 modified "2023-09-23" @default.
- W1001551729 title "Chapter 8 Polyanionic Agents and Inhibition of Phagosome-Lysosome Fusion: Paradox Lost" @default.
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- W1001551729 doi "https://doi.org/10.1016/s0070-2161(08)60136-7" @default.
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