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- W1001594836 abstract "The glucocorticoid cascade hypothesis of stress and aging is an attempt to formulate a causal relationship between the activity of the hypothalamicpituitary-adrenal axis (HPA axis) and the deleterious consequences of the actions of glucocorticoids upon the viability of cells in the brain as well as their structure and function. This chapter discusses the hypothesis in the light of old and new evidence on the aging of the HPA axis and the role of glucocorticoids in the generation of neural damage. The hypothesis is based on two lines of evidence: (1) that glucocorticoids cause hippocampal damage and (2) that hippocampal damage results in pituitary–adrenal hypersecretion. The chapter also presents some features of the results, such as a rat ages; there is a general decline in the plasticity of the brain to respond to environmental challenges, and with increasing age, there is increased vulnerability to stress-induced loss of hippocampal neurons. The glucocorticoid cascade hypothesis of stress and aging has served well as a stimulus and guide for research on endocrine factors in the aging of the brain; however, much more needs to be learned to uncover basic cellular mechanisms and to account for the sometimes disturbing variability among studies and among individual animals in their susceptibility to negative effects of stress and in degenerative changes in the brain." @default.
- W1001594836 created "2016-06-24" @default.
- W1001594836 creator A5035103174 @default.
- W1001594836 date "1992-01-01" @default.
- W1001594836 modified "2023-10-17" @default.
- W1001594836 title "Chapter 26 Re-examination of the glucocorticoid hypothesis of stress and aging" @default.
- W1001594836 cites W113607289 @default.
- W1001594836 cites W1489028475 @default.
- W1001594836 cites W1536700299 @default.
- W1001594836 cites W1550462067 @default.
- W1001594836 cites W1591042414 @default.
- W1001594836 cites W1642124290 @default.
- W1001594836 cites W1774751156 @default.
- W1001594836 cites W1963927964 @default.
- W1001594836 cites W1966157184 @default.
- W1001594836 cites W1972088226 @default.
- W1001594836 cites W1975901872 @default.
- W1001594836 cites W1977143695 @default.
- W1001594836 cites W1982692135 @default.
- W1001594836 cites W1985114728 @default.
- W1001594836 cites W1985341495 @default.
- W1001594836 cites W1988102641 @default.
- W1001594836 cites W1990677727 @default.
- W1001594836 cites W1992026104 @default.
- W1001594836 cites W1992152672 @default.
- W1001594836 cites W1995549578 @default.
- W1001594836 cites W1998729594 @default.
- W1001594836 cites W2002264389 @default.
- W1001594836 cites W2007169317 @default.
- W1001594836 cites W2008050722 @default.
- W1001594836 cites W2008809070 @default.
- W1001594836 cites W2011669749 @default.
- W1001594836 cites W2011755611 @default.
- W1001594836 cites W2014212152 @default.
- W1001594836 cites W2015497140 @default.
- W1001594836 cites W2017000399 @default.
- W1001594836 cites W2018203792 @default.
- W1001594836 cites W2020968275 @default.
- W1001594836 cites W2022658269 @default.
- W1001594836 cites W2023716469 @default.
- W1001594836 cites W2023928170 @default.
- W1001594836 cites W2024255841 @default.
- W1001594836 cites W2026812475 @default.
- W1001594836 cites W2029417981 @default.
- W1001594836 cites W2029777334 @default.
- W1001594836 cites W2031062169 @default.
- W1001594836 cites W2032281246 @default.
- W1001594836 cites W2032651138 @default.
- W1001594836 cites W2033948248 @default.
- W1001594836 cites W2034694738 @default.
- W1001594836 cites W2036587591 @default.
- W1001594836 cites W2039711411 @default.
- W1001594836 cites W2040570367 @default.
- W1001594836 cites W2043476900 @default.
- W1001594836 cites W2043907950 @default.
- W1001594836 cites W2045534445 @default.
- W1001594836 cites W2046177214 @default.
- W1001594836 cites W2046895321 @default.
- W1001594836 cites W2047981877 @default.
- W1001594836 cites W2053350861 @default.
- W1001594836 cites W2056138533 @default.
- W1001594836 cites W2056408203 @default.
- W1001594836 cites W2056992784 @default.
- W1001594836 cites W2057783377 @default.
- W1001594836 cites W2060644077 @default.
- W1001594836 cites W2062815214 @default.
- W1001594836 cites W2065159884 @default.
- W1001594836 cites W2069929495 @default.
- W1001594836 cites W2074802748 @default.
- W1001594836 cites W2078288069 @default.
- W1001594836 cites W2081647098 @default.
- W1001594836 cites W2087368034 @default.
- W1001594836 cites W2087986775 @default.
- W1001594836 cites W2090093640 @default.
- W1001594836 cites W2093500055 @default.
- W1001594836 cites W2097013135 @default.
- W1001594836 cites W2105368889 @default.
- W1001594836 cites W2134033459 @default.
- W1001594836 cites W2145827936 @default.
- W1001594836 cites W2155456788 @default.
- W1001594836 cites W2162943890 @default.
- W1001594836 cites W2162972693 @default.
- W1001594836 cites W2164626680 @default.
- W1001594836 cites W2321972530 @default.
- W1001594836 doi "https://doi.org/10.1016/s0079-6123(08)64585-9" @default.
- W1001594836 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1480759" @default.
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